LCN2

Across TCGA patient cohorts, LCN2 protein abundance is significantly associated with the RNA expression of many other genes, with 15,743 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible LCN2-associated genes across cancer lineages are CXCL8, CEACAM3, and VNN3. Each is linked with LCN2 in more than 9 cancer types. Because this analysis shows association rather than direction, both LCN2-to-partner and partner-to-LCN2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LCN2 versus CXCL8 in LUAD, with a Pearson correlation of 0.72.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LCN2→partner) and Y-score (partner→LCN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CXCL8 →	+2.471	+1.211	<.001	<.001	3	10
LSCC	CEACAM3 →	+0.888	+1.380	<.001	<.001	3	10
UCEC	VNN3 →	+1.210	+0.877	<.001	<.001	3	10
GBM	PI3 →	+2.675	+1.482	<.001	<.001	3	9
GBM	CXCL3 →	+1.451	+1.557	<.001	<.001	3	9
LSCC	ZC3H12A →	+1.066	+1.179	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,743 associations by consensus.

LCN2 vs CXCL8 — LUAD

Explore this scatter interactively →