LCN2

Across TCGA patient cohorts, LCN2 mutation is significantly associated with the RNA expression of many other genes, with 456 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LCN2-associated genes across cancer lineages are MIA-RAB4B, FTH1P9, and RNU6-1174P. Each is linked with LCN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both LCN2-to-partner and partner-to-LCN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIA-RAB4B grouped by LCN2-low versus LCN2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LCN2→partner) and Y-score (partner→LCN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIA-RAB4B →	+0.089	+2.670	<.001	.002	3	2
SKCM	FTH1P9 →	+0.034	+4.906	<.001	.001	3	2
SKCM	RNU6-1174P →	+0.185	+3.186	<.001	.006	3	2
UCEC	RN7SL454P →	+0.183	+3.101	.007	<.001	3	2
SKCM	RNA5SP388 →	+0.125	+3.897	<.001	.009	3	2
COAD	RNU6-1167P →	+0.392	+7.741	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 456 associations by consensus.

MIA-RAB4B by LCN2 expression — UCEC

Explore this box plot interactively →