LCN2

Across TCGA cell cohorts, LCN2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,677 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible LCN2-associated GO terms across cancer lineages are Positive regulation of iron ion transport, Positive regulation of iron ion transmembrane transport, and Negative regulation of hippocampal neuron apoptotic process. Each is linked with LCN2 in more than 15 cancer types. Because this analysis shows association rather than direction, both LCN2-to-partner and partner-to-LCN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of iron ion transport grouped by LCN2-low versus LCN2-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LCN2→partner) and Y-score (partner→LCN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Positive regulation of iron ion transport →	+2.214	+6.435	<.001	<.001	3	16
OVARY	Positive regulation of iron ion transmembrane transport →	+2.214	+6.435	<.001	<.001	3	16
STOMACH	Negative regulation of hippocampal neuron apoptotic process →	+1.968	+5.748	<.001	<.001	3	14
STOMACH	Regulation of hippocampal neuron apoptotic process →	+2.087	+5.748	<.001	<.001	3	13
OVARY	Positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay →	+0.109	+3.638	.001	.002	3	12
UPPER_AERODIGESTIVE_TRACT	Cellular response to steroid hormone stimulus →	+0.105	+4.340	<.001	.003	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,677 associations by consensus.

Positive regulation of iron ion transport by LCN2 expression — OVARY

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