LCN1P1

Across TCGA pan-cancer cohorts, LCN1P1 RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated LCN1P1 data layer compared with 1 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher LCN1P1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated LCN1P1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LIHC show a favorable association.

UVM, HNSC, and UCS are the cancer types where LCN1P1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Tertile	All	0.530	0.960	<.001	102	view →
HNSC	DFS	Median	IV	0.735	0.556	<.001	81	view →
UCS	DFS	Tertile	III,IV	0.123	0.460	.004	40	view →
READ	DFS	Quartile	II,III,IV	0.199	1.000	<.001	38	view →
UCEC	DFS	Quartile	All	0.851	0.913	.005	18	view →
LIHC	DFS	Tertile	II,III,IV	0.564	0.149	.022	18	view →
STAD	OS	Median	III,IV	0.612	0.337	.011	15	view →
COAD	DFS	Tertile	All	0.447	0.638	.009	15	view →
THYM	DFS	Median	II,III,IV	0.947	0.562	.012	9	view →
SKCM	DFS	Tertile	IV	0.016	0.541	.008	9	view →
CESC	OS	Tertile	All	0.929	0.837	.028	4	view →
BLCA	OS	Quartile	All	0.799	0.683	.029	4	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

LCN1P1–UVM (OS)

Open the UVM breakdown →