Across TCGA patient cohorts, LCN10 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LCN10-associated genes across cancer lineages are 14-3-3_beta, p27_pT157, and Fibronectin. Each is linked with LCN10 in more than 1 cancer types. Because this analysis shows association rather than direction, both LCN10-to-partner and partner-to-LCN10 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LCN10→partner) and Y-score (partner→LCN10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.134	-2.986	.021	.037	3	1
UCEC	p27_pT157 →	-0.072	-3.000	.031	.037	3	1
UCEC	Fibronectin →	-0.443	-3.000	.020	.037	1	1
UCEC	p90 RSK →	+0.324	+3.013	.003	.019	1	1
UCEC	Rab11 →	-0.223	-3.000	.007	.037	1	1
UCEC	Annexin-1 →	+0.783	+3.000	.010	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Exploration

LCN10 survival (RNA) · tumor vs normal (RNA) · all LCN10 data types