LCMT2

Across TCGA patient cohorts, LCMT2 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LCMT2-associated genes across cancer lineages are STAT3_pY705, INPP4B, and JNK2. Each is linked with LCMT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both LCMT2-to-partner and partner-to-LCMT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by LCMT2-low versus LCMT2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LCMT2→partner) and Y-score (partner→LCMT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.467	-2.311	<.001	.034	3	2
UCEC	INPP4B →	-0.351	-2.459	.016	.019	3	1
UCEC	JNK2 →	+0.267	+3.196	.002	.009	3	1
UCEC	Notch1 →	+0.168	+2.700	.007	.006	3	1
UCEC	PCNA →	+0.296	+3.807	.002	<.001	3	1
UCEC	PDCD4 →	-0.518	-2.312	.014	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

STAT3_pY705 by LCMT2 expression — UCEC

Explore this box plot interactively →