LCMT2

Across TCGA cell cohorts, LCMT2 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LCMT2-associated genes across cancer lineages are CST5, PRSS58, and CCDC185. Each is linked with LCMT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both LCMT2-to-partner and partner-to-LCMT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CST5 grouped by LCMT2-low versus LCMT2-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LCMT2→partner) and Y-score (partner→LCMT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CST5 →	+0.113	+4.981	<.001	.008	3	2
PANCREAS	PRSS58 →	+0.092	+5.000	<.001	.006	3	1
SOFT_TISSUE	CCDC185 →	+0.048	+4.635	<.001	.003	3	1
SOFT_TISSUE	C9orf92 →	+0.144	+4.369	<.001	.008	3	1
OVARY	IFNA17 →	+0.020	+5.807	<.001	.001	3	1
UPPER_AERODIGESTIVE_TRACT	UTF1 →	+0.170	+4.357	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

CST5 by LCMT2 expression — CNS

Explore this box plot interactively →