Across TCGA patient cohorts, LCMT1 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LCMT1-associated genes across cancer lineages are 14-3-3_beta, eEF2, and FoxM1. Each is linked with LCMT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LCMT1-to-partner and partner-to-LCMT1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LCMT1→partner) and Y-score (partner→LCMT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.115	-2.973	.017	.035	3	1
UCEC	eEF2 →	+0.548	+3.321	.001	.010	3	1
UCEC	FoxM1 →	+0.267	+2.459	.032	.020	3	1
UCEC	MSH2 →	-0.311	-3.143	.005	.018	3	1
UCEC	Annexin-1 →	+0.527	+2.827	.038	.035	3	1
UCEC	Rictor_pT1135 →	-0.102	-3.169	.038	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Exploration

LCMT1 survival (RNA) · tumor vs normal (RNA) · all LCMT1 data types