LCLAT1

Across TCGA patient cohorts, LCLAT1 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LCLAT1-associated genes across cancer lineages are FASN, Acetyl-a-Tubulin-Lys40, and MEK1. Each is linked with LCLAT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LCLAT1-to-partner and partner-to-LCLAT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by LCLAT1-low versus LCLAT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LCLAT1→partner) and Y-score (partner→LCLAT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.352	+3.584	.015	.002	3	2
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.528	+1.847	.004	.008	3	2
UCEC	MEK1 →	+0.451	+3.584	<.001	.002	3	2
UCEC	STAT3_pY705 →	-0.442	-2.415	<.001	.002	3	2
UCEC	ASNS →	+0.533	+2.000	<.001	.029	3	2
UCEC	C-Raf →	+0.193	+1.807	<.001	.025	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

FASN by LCLAT1 expression — UCEC

Explore this box plot interactively →