LCLAT1

Across TCGA cell cohorts, LCLAT1 mutation is significantly associated with the drug of many other genes, with 21 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LCLAT1-associated genes across cancer lineages are Entospletinib, AGI-6780, and Dihydrorotenone. Each is linked with LCLAT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LCLAT1-to-partner and partner-to-LCLAT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Entospletinib grouped by LCLAT1-low versus LCLAT1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LCLAT1→partner) and Y-score (partner→LCLAT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Entospletinib →	+0.389	+2.646	.043	.047	3	1
LARGE_INTESTINE	AGI-6780 →	+0.403	+2.646	.038	.047	3	1
LARGE_INTESTINE	Dihydrorotenone →	+0.574	+2.649	.004	.046	3	1
LARGE_INTESTINE	741909 →	+0.721	+2.649	.005	.046	3	1
LARGE_INTESTINE	743380 →	+0.801	+2.649	.002	.046	3	1
LARGE_INTESTINE	AZD5991 →	+1.194	+2.649	.001	.046	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Entospletinib by LCLAT1 expression — LARGE_INTESTINE

Explore this box plot interactively →