Across TCGA patient cohorts, LCK mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LCK-associated genes across cancer lineages are Caspase-8, eIF4E, and JNK2. Each is linked with LCK in more than 1 cancer types. Because this analysis shows association rather than direction, both LCK-to-partner and partner-to-LCK results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LCK→partner) and Y-score (partner→LCK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-8 →	-0.212	-1.906	.036	.016	3	2
UCEC	eIF4E →	+0.193	+3.183	.022	.009	3	1
UCEC	JNK2 →	+0.249	+2.196	.001	.032	3	1
UCEC	MEK1 →	+0.412	+1.906	.005	.016	3	1
UCEC	Rab11 →	-0.125	-1.906	.032	.016	3	1
UCEC	STAT3_pY705 →	-0.464	-2.700	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

Exploration

LCK survival (RNA) · tumor vs normal (RNA) · all LCK data types