LCK

RNA expression — cross-omics
Cross-omicsRNA → FUNCTION-RNACell-linePairwise association · TCGA cohorts

Across TCGA cell cohorts, LCK RNA expression is significantly associated with the go_rna of many other GO terms, with 4,440 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LCK-associated GO terms across cancer lineages are Positive regulation of protein import into nucleus, Response to indole-3-methanol, and Cellular response to indole-3-methanol. Each is linked with LCK in more than 7 cancer types. Because this analysis shows association rather than direction, both LCK-to-partner and partner-to-LCK results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LCK→partner) and Y-score (partner→LCK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner GO termX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
URINARY_TRACTPositive regulation of protein import into nucleus →+0.103+0.950.001.00838
LUNG_SCLCResponse to indole-3-methanol →+0.239+3.309<.001<.00138
LUNG_SCLCCellular response to indole-3-methanol →+0.166+2.127<.001.00138
STOMACHSerotonin secretion →+1.206+1.454.002<.00137
STOMACHResponse to molecule of fungal origin →+1.543+1.753<.001<.00137
STOMACHSerotonin production involved in inflammatory response →+1.206+1.454.002<.00137
Each partner links to its Q-omics profile. Showing the 6 strongest of 4,440 associations by consensus.

Exploration