Across TCGA patient cohorts, LCE4A mutation is significantly associated with the RNA expression of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LCE4A-associated genes across cancer lineages are MIR6085, RNU6-775P, and OR5L2. Each is linked with LCE4A in more than 1 cancer types. Because this analysis shows association rather than direction, both LCE4A-to-partner and partner-to-LCE4A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LCE4A→partner) and Y-score (partner→LCE4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR6085 →	+0.581	+2.958	.001	.005	3	1
SKCM	RNU6-775P →	+0.428	+7.816	<.001	.008	3	1
LUAD	OR5L2 →	+0.034	+7.930	<.001	.008	3	1
LUAD	AARS1P1 →	+0.069	+7.930	<.001	.008	3	1
LUAD	RNU6-751P →	+0.427	+7.930	<.001	.008	3	1
LUAD	MIR4695 →	+0.348	+7.930	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

Exploration

LCE4A survival (RNA) · tumor vs normal (RNA) · all LCE4A data types