Across TCGA patient cohorts, LCE4A mutation is significantly associated with the total protein of many other genes, with 2 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LCE4A-associated genes across cancer lineages are Caspase-7-cleavedD198 and c-Met_pY1235. Each is linked with LCE4A in more than 1 cancer types. Because this analysis shows association rather than direction, both LCE4A-to-partner and partner-to-LCE4A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LCE4A→partner) and Y-score (partner→LCE4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+1.082	+2.827	.002	.035	3	1
UCEC	c-Met_pY1235 →	+0.090	+2.817	.048	.036	2	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

Exploration

LCE4A survival (RNA) · tumor vs normal (RNA) · all LCE4A data types