Across TCGA patient cohorts, LCE3A mutation is significantly associated with the RNA expression of many other genes, with 30 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible LCE3A-associated genes across cancer lineages are RNU2-71P, GIMD1, and PLLPP1. Each is linked with LCE3A in more than 1 cancer types. Because this analysis shows association rather than direction, both LCE3A-to-partner and partner-to-LCE3A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LCE3A→partner) and Y-score (partner→LCE3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU2-71P →	+0.363	+5.292	<.001	.006	3	2
BLCA	GIMD1 →	+0.144	+7.640	<.001	.009	3	2
SKCM	PLLPP1 →	+0.106	+5.594	<.001	.004	3	1
SKCM	PGAM1P1 →	+0.095	+5.867	<.001	.003	3	1
SKCM	TRBV26 →	+0.148	+5.594	<.001	.004	3	1
SKCM	MTCO2P24 →	+0.124	+5.771	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

Exploration

LCE3A survival (RNA) · tumor vs normal (RNA) · all LCE3A data types