Across TCGA pan-cancer cohorts, LCE2D RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of LCE2D’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where LCE2D RNA is repressed in tumor relative to normal tissue. In most cancer types LCE2D is over-expressed in tumor, although a few such as KIRP and KIRC show the opposite, repressed pattern.

KIRP, KIRC, and CHOL are the cancer types where LCE2D tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LCE2D RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	II,III,IV	−0.378	<.001	11	view →
KIRC	All	All	−0.199	<.001	8	view →
CHOL	All	All	−0.246	.003	4	view →
KICH	All	All	−0.184	.006	2	view →
LUSC	Male	All	+0.166	.003	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: LCE2D RNA expression & survival · all LCE2D data types