Across TCGA patient cohorts, LCE1B mutation is significantly associated with the RNA expression of many other genes, with 640 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LCE1B-associated genes across cancer lineages are TMEM251, FXN, and RRM1. Each is linked with LCE1B in more than 1 cancer types. Because this analysis shows association rather than direction, both LCE1B-to-partner and partner-to-LCE1B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LCE1B→partner) and Y-score (partner→LCE1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TMEM251 →	+0.626	+3.475	.003	.002	3	2
UCEC	FXN →	+0.558	+3.711	.001	<.001	3	2
UCEC	RRM1 →	+0.888	+3.343	.001	.005	3	2
UCEC	SRP68 →	+0.454	+3.711	.005	<.001	3	2
UCEC	ZNF57 →	+0.480	+3.467	.001	.002	3	2
UCEC	NDUFAB1 →	+0.556	+3.508	.003	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 640 associations by consensus.

Exploration

LCE1B survival (RNA) · tumor vs normal (RNA) · all LCE1B data types