Across TCGA pan-cancer cohorts, LCAT mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of LCAT’s most consistent transcriptional readouts.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where LCAT mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types LCAT is over-expressed in tumor, although a few such as HNSC and LUAD show the opposite, repressed pattern.
HNSC, LUAD, and LSCC are the cancer types where LCAT tumor–normal differential expression is most reproducible.
mass-spec protein tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LCAT mass-spec protein (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.