Across TCGA patient cohorts, LCAT mutation is significantly associated with the RNA expression of many other genes, with 321 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LCAT-associated genes across cancer lineages are RNA5SP461, RN7SL763P, and RNU6-1194P. Each is linked with LCAT in more than 1 cancer types. Because this analysis shows association rather than direction, both LCAT-to-partner and partner-to-LCAT results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LCAT→partner) and Y-score (partner→LCAT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNA5SP461 →	+0.468	+7.816	<.001	.008	3	2
SKCM	RN7SL763P →	+0.119	+7.816	<.001	.008	3	2
COAD	RNU6-1194P →	+0.785	+7.741	<.001	.009	3	2
BRCA	WBP1LP8 →	+0.159	+9.057	<.001	.003	3	1
LIHC	SMG6-IT1 →	+0.148	+6.149	<.001	.002	3	1
CESC	PTMAP6 →	+0.239	+5.127	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 321 associations by consensus.

Exploration

LCAT survival (RNA) · tumor vs normal (RNA) · all LCAT data types