Across TCGA patient cohorts, LCAT mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LCAT-associated genes across cancer lineages are MEK1, ATM, and CD20. Each is linked with LCAT in more than 1 cancer types. Because this analysis shows association rather than direction, both LCAT-to-partner and partner-to-LCAT results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LCAT→partner) and Y-score (partner→LCAT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.530	+3.321	.005	.010	3	1
UCEC	ATM →	-0.704	-3.000	.003	.036	3	1
UCEC	CD20 →	+0.136	+3.189	.048	.010	3	1
UCEC	PCNA →	+0.302	+3.169	.007	.019	2	1
UCEC	ERK2 →	+0.261	+3.321	.009	.010	1	1
UCEC	Rad50 →	-0.307	-3.321	.015	.010	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Exploration

LCAT survival (RNA) · tumor vs normal (RNA) · all LCAT data types