Across TCGA cell cohorts, LCAT mutation is significantly associated with the RNA expression of many other genes, with 24 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LCAT-associated genes across cancer lineages are FSHB, AVP, and H1-1. Each is linked with LCAT in more than 1 cancer types. Because this analysis shows association rather than direction, both LCAT-to-partner and partner-to-LCAT results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LCAT→partner) and Y-score (partner→LCAT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	FSHB →	+0.012	+5.247	<.001	.001	3	1
LARGE_INTESTINE	AVP →	+0.068	+4.217	<.001	.001	3	1
LARGE_INTESTINE	H1-1 →	+0.097	+4.054	<.001	.004	3	1
LARGE_INTESTINE	OR10Q1 →	+0.110	+3.920	.001	.005	3	1
BLOOD_Leukemia	C20orf173 →	+0.057	+2.870	.001	.005	3	1
BLOOD_Leukemia	FAM71F1 →	+0.166	+4.058	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Exploration

LCAT survival (RNA) · tumor vs normal (RNA) · all LCAT data types