LCA5

Across TCGA pan-cancer cohorts, LCA5 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated LCA5 data layer compared with 23 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher LCA5 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated LCA5 expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

PDAC, LUAD, and HNSC are the cancer types where LCA5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Tertile	All	0.705	1.000	.004	26	view →
LUAD	OS	Quartile	All	0.917	0.545	.002	9	view →
HNSC	DFS	Tertile	All	0.353	0.915	.024	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

LCA5–PDAC (OS)

Open the PDAC breakdown →