LCA5

Across TCGA patient cohorts, LCA5 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LCA5-associated genes across cancer lineages are p62 Lck ligand, eEF2K, and ACC_pS79. Each is linked with LCA5 in more than 1 cancer types. Because this analysis shows association rather than direction, both LCA5-to-partner and partner-to-LCA5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by LCA5-low versus LCA5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LCA5→partner) and Y-score (partner→LCA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.237	+2.009	.039	.017	3	2
UCEC	eEF2K →	+0.244	+2.584	.048	.010	3	2
SKCM	ACC_pS79 →	+0.410	+3.459	.004	.005	3	1
SKCM	PKC-a →	-0.399	-2.321	.049	.035	3	1
UCEC	14-3-3_beta →	-0.080	-1.973	.024	.029	3	1
UCEC	eIF4E →	+0.189	+3.183	.011	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

p62 Lck ligand by LCA5 expression — UCEC

Explore this box plot interactively →