LCA5

Across TCGA cell cohorts, LCA5 mutation is significantly associated with the RNA expression of many other genes, with 51 significant associations in total. PANCREAS shows the largest number of these associations.

The most reproducible LCA5-associated genes across cancer lineages are MS4A2, PRPH2, and NPHS2. Each is linked with LCA5 in more than 1 cancer types. Because this analysis shows association rather than direction, both LCA5-to-partner and partner-to-LCA5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MS4A2 grouped by LCA5-low versus LCA5-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LCA5→partner) and Y-score (partner→LCA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	MS4A2 →	+0.007	+2.827	.001	.004	3	2
PANCREAS	PRPH2 →	+0.092	+3.714	.005	.002	3	1
PANCREAS	NPHS2 →	+0.016	+2.841	.005	.007	3	1
PANCREAS	GRIA2 →	+0.051	+3.459	.001	.005	3	1
PANCREAS	PRM2 →	+0.064	+3.584	<.001	.001	3	1
PANCREAS	SLC10A2 →	+0.011	+2.841	.005	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

MS4A2 by LCA5 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →