LBX2

Across TCGA patient cohorts, LBX2 mutation is significantly associated with the RNA expression of many other genes, with 113 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LBX2-associated genes across cancer lineages are RNU6-1180P, MIR328, and RNU6-1149P. Each is linked with LBX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both LBX2-to-partner and partner-to-LBX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1180P grouped by LBX2-low versus LBX2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LBX2→partner) and Y-score (partner→LBX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-1180P →	+0.246	+4.292	<.001	.006	3	2
UCEC	MIR328 →	+0.744	+3.318	<.001	.002	3	2
UCEC	RNU6-1149P →	+0.305	+3.198	.006	.009	3	2
COAD	WDR7-OT1 →	+0.303	+5.693	<.001	.003	3	2
UCEC	MIR425 →	+0.520	+2.914	.002	.008	3	1
UCEC	RNU4-51P →	+0.491	+4.088	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 113 associations by consensus.

RNU6-1180P by LBX2 expression — UCEC

Explore this box plot interactively →