LBR

Across TCGA pan-cancer cohorts, LBR mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated LBR data layer compared with 28 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher LBR mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated LBR expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

UCEC, LUAD, and HNSC are the cancer types where LBR mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.801	0.928	.045	6	view →
LUAD	OS	Median	III,IV	0.216	0.629	.009	3	view →
HNSC	OS	Tertile	III,IV	0.799	0.558	.048	1	view →
GBM	DFS	Quartile	All	0.639	0.878	.046	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

LBR–UCEC (DFS)

Open the UCEC breakdown →