LBR

Across TCGA patient cohorts, LBR mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LBR-associated genes across cancer lineages are ASNS, eIF4E, and C-Raf. Each is linked with LBR in more than 2 cancer types. Because this analysis shows association rather than direction, both LBR-to-partner and partner-to-LBR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by LBR-low versus LBR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LBR→partner) and Y-score (partner→LBR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.468	+1.584	<.001	.034	3	3
UCEC	eIF4E →	+0.176	+2.321	.026	.034	2	3
UCEC	C-Raf →	+0.114	+2.222	.033	.010	3	2
UCEC	14-3-3_beta →	-0.113	-2.156	.002	.003	3	1
UCEC	Fibronectin →	-0.245	-2.105	.047	.017	3	1
UCEC	MEK1 →	+0.417	+2.807	.002	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

ASNS by LBR expression — UCEC

Explore this box plot interactively →