LBR

Across TCGA cell cohorts, LBR RNA expression is significantly associated with the go_rna of many other GO terms, with 4,873 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible LBR-associated GO terms across cancer lineages are Nuclear pore complex assembly, Mitotic sister chromatid segregation, and Regulation of DNA-templated DNA replication. Each is linked with LBR in more than 15 cancer types. Because this analysis shows association rather than direction, both LBR-to-partner and partner-to-LBR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nuclear pore complex assembly grouped by LBR-low versus LBR-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LBR→partner) and Y-score (partner→LBR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Nuclear pore complex assembly →	+0.185	+1.527	<.001	<.001	3	16
SKIN	Mitotic sister chromatid segregation →	+0.113	+1.116	<.001	<.001	3	16
BONE	Regulation of DNA-templated DNA replication →	+0.117	+1.189	.002	.001	3	15
KIDNEY	Positive regulation of mitotic sister chromatid separation →	+0.144	+1.007	<.001	<.001	3	15
BREAST	Metaphase chromosome alignment →	+0.105	+1.149	<.001	<.001	3	15
SOFT_TISSUE	Mitotic nuclear division →	+0.105	+1.613	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,873 associations by consensus.

Nuclear pore complex assembly by LBR expression — BREAST

Explore this box plot interactively →