LBR

Across TCGA cell cohorts, LBR mutation is significantly associated with the drug of many other genes, with 56 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LBR-associated genes across cancer lineages are CCT007093, Bromosporine, and SGC-CBP30. Each is linked with LBR in more than 1 cancer types. Because this analysis shows association rather than direction, both LBR-to-partner and partner-to-LBR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCT007093 grouped by LBR-low versus LBR-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LBR→partner) and Y-score (partner→LBR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CCT007093 →	+0.310	+2.649	.037	.046	3	1
LARGE_INTESTINE	Bromosporine →	+0.343	+2.649	.046	.046	3	1
LARGE_INTESTINE	SGC-CBP30 →	+0.300	+2.649	.034	.046	3	1
LARGE_INTESTINE	CZC24832 →	+0.309	+2.646	.016	.047	3	1
LARGE_INTESTINE	AZD5153 →	+0.757	+2.710	.002	.027	3	1
LARGE_INTESTINE	VSP34_8731 →	+0.399	+2.649	.048	.046	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

CCT007093 by LBR expression — LARGE_INTESTINE

Explore this box plot interactively →