Across TCGA pan-cancer cohorts, LBH mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated LBH data layer compared with 25 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher LBH mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated LBH expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

CCRCC, LSCC, and LUAD are the cancer types where LBH mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.877	0.616	<.001	81	view →
LSCC	DFS	Tertile	II,III,IV	0.464	0.896	.002	23	view →
LUAD	DFS	Median	III,IV	0.295	0.745	.001	11	view →
HNSC	OS	Median	All	1.000	0.484	.038	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: LBH tumor-vs-normal RNA expression · all LBH data types