Across TCGA patient cohorts, LBH mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LBH-associated genes across cancer lineages are 14-3-3_beta, eIF4G, and ERK2. Each is linked with LBH in more than 1 cancer types. Because this analysis shows association rather than direction, both LBH-to-partner and partner-to-LBH results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LBH→partner) and Y-score (partner→LBH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.115	-2.301	.014	.034	3	1
UCEC	eIF4G →	+0.360	+2.999	.012	.035	3	1
UCEC	ERK2 →	+0.283	+3.321	.001	.010	3	1
UCEC	Gab2 →	+0.431	+3.000	.009	.036	3	1
UCEC	GAPDH →	+0.662	+2.321	.008	.034	3	1
UCEC	Heregulin →	-0.130	-2.321	.024	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

Exploration

LBH survival (RNA) · tumor vs normal (RNA) · all LBH data types