Across TCGA pan-cancer cohorts, LAYN mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of LAYN’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where LAYN mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types LAYN is over-expressed in tumor, although a few such as LSCC and LUAD show the opposite, repressed pattern.

PDAC, LSCC, and LUAD are the cancer types where LAYN tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LAYN mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PDAC	Female	All	+1.654	<.001	8	view →
LSCC	All	III,IV	−0.861	<.001	7	view →
LUAD	Female	All	−2.231	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: LAYN RNA expression & survival · all LAYN data types