Across TCGA patient cohorts, LAYN protein abundance is significantly associated with the RNA expression of many other genes, with 3,500 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible LAYN-associated genes across cancer lineages are NDN, DIO3, and EPHA3. Each is linked with LAYN in more than 3 cancer types. Because this analysis shows association rather than direction, both LAYN-to-partner and partner-to-LAYN results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAYN→partner) and Y-score (partner→LAYN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	NDN →	+2.041	+0.516	<.001	.005	3	3
PDAC	DIO3 →	+1.066	+0.811	.007	.001	3	3
GBM	EPHA3 →	+1.670	+0.501	.006	.009	2	4
BRCA	AMOTL2 →	+1.250	+1.273	<.001	.003	3	2
GBM	SCPEP1 →	+0.761	+0.546	.005	.004	3	2
GBM	TRERF1 →	-0.565	-0.440	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,500 associations by consensus.

Exploration

LAYN survival (RNA) · tumor vs normal (RNA) · all LAYN data types