Across TCGA patient cohorts, LAYN mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LAYN-associated genes across cancer lineages are PKC-delta_pS664, ATM, and C-Raf. Each is linked with LAYN in more than 1 cancer types. Because this analysis shows association rather than direction, both LAYN-to-partner and partner-to-LAYN results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAYN→partner) and Y-score (partner→LAYN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PKC-delta_pS664 →	-0.127	-2.449	.012	.019	3	2
UCEC	ATM →	-0.708	-3.446	<.001	.005	3	2
UCEC	C-Raf →	+0.198	+2.222	.001	.011	3	2
UCEC	Cyclin-E2 →	+0.195	+2.469	.006	.010	3	2
UCEC	EGFR_pY1068 →	-0.268	-2.459	.011	.019	3	1
UCEC	eIF4G →	+0.321	+1.700	.014	.044	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

Exploration

LAYN survival (RNA) · tumor vs normal (RNA) · all LAYN data types