Across TCGA cell cohorts, LAYN mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LAYN-associated genes across cancer lineages are PPP1R2C, TBC1D21, and OR52H1. Each is linked with LAYN in more than 1 cancer types. Because this analysis shows association rather than direction, both LAYN-to-partner and partner-to-LAYN results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAYN→partner) and Y-score (partner→LAYN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PPP1R2C →	+0.035	+3.510	<.001	.003	3	1
LARGE_INTESTINE	TBC1D21 →	+0.010	+4.022	<.001	.006	3	1
LARGE_INTESTINE	OR52H1 →	+0.025	+3.347	<.001	.005	3	1
LARGE_INTESTINE	OR2Z1 →	+0.010	+4.022	<.001	.006	3	1
LARGE_INTESTINE	IQCF5 →	+0.025	+4.022	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Exploration

LAYN survival (RNA) · tumor vs normal (RNA) · all LAYN data types