LATS2

Across TCGA cell cohorts, LATS2 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,984 significant associations in total. BONE shows the largest number of these associations.

The most reproducible LATS2-associated GO terms across cancer lineages are Hippo signaling, Negative regulation of cell growth involved in contact inhibition, and Contact inhibition. Each is linked with LATS2 in more than 16 cancer types. Because this analysis shows association rather than direction, both LATS2-to-partner and partner-to-LATS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Hippo signaling grouped by LATS2-low versus LATS2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LATS2→partner) and Y-score (partner→LATS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Hippo signaling →	+0.137	+1.203	.001	.003	3	17
LARGE_INTESTINE	Negative regulation of cell growth involved in contact inhibition →	+0.220	+1.184	.005	<.001	3	15
SKIN	Contact inhibition →	+0.127	+0.734	<.001	<.001	3	13
LARGE_INTESTINE	Detection of cell density →	+0.136	+1.234	<.001	<.001	3	13
KIDNEY	Regulation of modification of synaptic structure →	+0.110	+1.028	.002	.007	3	13
STOMACH	Regulation of hippo signaling →	+0.088	+1.351	.002	.008	2	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,984 associations by consensus.

Hippo signaling by LATS2 expression — BONE

Explore this box plot interactively →