LATS2

Across TCGA cell cohorts, LATS2 mutation is significantly associated with the RNA expression of many other genes, with 804 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LATS2-associated genes across cancer lineages are ACTL9, OR2T29, and OR2G6. Each is linked with LATS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both LATS2-to-partner and partner-to-LATS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACTL9 grouped by LATS2-low versus LATS2-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LATS2→partner) and Y-score (partner→LATS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ACTL9 →	+0.421	+4.930	<.001	.008	3	2
SOFT_TISSUE	OR2T29 →	+0.876	+5.369	<.001	.004	3	2
SOFT_TISSUE	OR2G6 →	+0.213	+5.977	<.001	.001	3	2
LUNG_NSCLC_LUAD	MTRNR2L10 →	+0.005	+3.944	<.001	.006	3	2
LUNG_SCLC	SSX7 →	+0.024	+4.058	<.001	.007	3	2
URINARY_TRACT	NOBOX →	+0.016	+4.044	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 804 associations by consensus.

ACTL9 by LATS2 expression — SOFT_TISSUE

Explore this box plot interactively →