LAT2

Across TCGA patient cohorts, LAT2 mutation is significantly associated with the RNA expression of many other genes, with 106 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible LAT2-associated genes across cancer lineages are SNRPGP12, RNU6-62P, and RN7SKP195. Each is linked with LAT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both LAT2-to-partner and partner-to-LAT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNRPGP12 grouped by LAT2-low versus LAT2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAT2→partner) and Y-score (partner→LAT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SNRPGP12 →	+0.485	+6.020	<.001	<.001	3	2
SKCM	RNU6-62P →	+0.599	+3.015	<.001	.009	3	1
SKCM	RN7SKP195 →	+0.068	+5.488	<.001	.001	3	1
SKCM	LINC02726 →	+0.201	+3.823	<.001	.001	3	1
SKCM	OR56A7P →	+0.022	+4.671	<.001	.004	3	1
SKCM	METTL8P1 →	+0.150	+3.580	.004	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 106 associations by consensus.

SNRPGP12 by LAT2 expression — COAD

Explore this box plot interactively →