LAT2

Across TCGA cell cohorts, LAT2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,600 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LAT2-associated GO terms across cancer lineages are Hepatocyte growth factor receptor signaling pathway, Protein localization to plasma membrane, and Negative regulation of small GTPase mediated signal transduction. Each is linked with LAT2 in more than 8 cancer types. Because this analysis shows association rather than direction, both LAT2-to-partner and partner-to-LAT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Hepatocyte growth factor receptor signaling pathway grouped by LAT2-low versus LAT2-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LAT2→partner) and Y-score (partner→LAT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Hepatocyte growth factor receptor signaling pathway →	+0.160	+1.601	.003	.002	3	9
CNS	Protein localization to plasma membrane →	+0.048	+0.695	<.001	<.001	3	8
SOFT_TISSUE	Negative regulation of small GTPase mediated signal transduction →	+0.060	+0.613	.005	.002	3	8
LUNG_SCLC	Arp2/3 complex-mediated actin nucleation →	+0.102	+1.581	<.001	<.001	3	8
LUNG_SCLC	Negative regulation of protein modification process →	+0.038	+1.441	.005	.002	3	8
CNS	MAPK cascade →	+0.039	+0.695	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,600 associations by consensus.

Hepatocyte growth factor receptor signaling pathway by LAT2 expression — PANCREAS

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