LAT2

Across TCGA cell cohorts, LAT2 mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LAT2-associated genes across cancer lineages are GFRA4, SAA4, and SLC25A31. Each is linked with LAT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both LAT2-to-partner and partner-to-LAT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GFRA4 grouped by LAT2-low versus LAT2-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAT2→partner) and Y-score (partner→LAT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	GFRA4 →	+0.022	+4.754	<.001	.005	3	1
LARGE_INTESTINE	SAA4 →	+0.683	+3.793	<.001	.007	3	1
LARGE_INTESTINE	SLC25A31 →	+0.073	+3.793	<.001	.007	3	1
LARGE_INTESTINE	SPIC →	+0.242	+4.510	<.001	.001	3	1
LARGE_INTESTINE	IFNL2 →	+0.595	+3.938	<.001	.005	3	1
LARGE_INTESTINE	LRRC55 →	+0.297	+3.793	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

GFRA4 by LAT2 expression — CNS

Explore this box plot interactively →