Across TCGA cell cohorts, LAT mutation is significantly associated with the RNA expression of many other genes, with 34 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LAT-associated genes across cancer lineages are GML, LGI1, and TSHB. Each is linked with LAT in more than 1 cancer types. Because this analysis shows association rather than direction, both LAT-to-partner and partner-to-LAT results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAT→partner) and Y-score (partner→LAT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GML →	+0.072	+4.567	<.001	.001	3	1
BLOOD_Leukemia	LGI1 →	+0.079	+5.124	<.001	<.001	3	1
BLOOD_Leukemia	TSHB →	+0.115	+4.691	.003	<.001	3	1
BLOOD_Leukemia	MMP27 →	+0.015	+4.384	<.001	.006	3	1
BLOOD_Leukemia	KRT71 →	+0.041	+4.507	<.001	.001	3	1
BLOOD_Leukemia	AWAT2 →	+0.012	+3.705	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

Exploration

LAT survival (RNA) · tumor vs normal (RNA) · all LAT data types