Across TCGA cell cohorts, LAT mutation is significantly associated with the mutation status of many other genes, with 1,047 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LAT-associated genes across cancer lineages are SETD3, RHBDL1, and PPP4C. Each is linked with LAT in more than 1 cancer types. Because this analysis shows association rather than direction, both LAT-to-partner and partner-to-LAT results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LAT→partner) and Y-score (partner→LAT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SETD3 →	+4.560	+4.309	.007	.007	1	2
BLOOD_Leukemia	RHBDL1 →	+3.338	+4.083	.003	.003	1	2
BLOOD_Leukemia	PPP4C →	+4.560	+4.309	.007	.007	1	2
BLOOD_Leukemia	DDAH2 →	+3.823	+4.430	.001	.001	1	1
BLOOD_Leukemia	REPIN1 →	+3.145	+3.932	.004	.004	1	1
BLOOD_Leukemia	TENM3 →	+2.037	+3.830	.008	.008	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,047 associations by consensus.

Exploration

LAT survival (RNA) · tumor vs normal (RNA) · all LAT data types