LASP1

Across TCGA pan-cancer cohorts, LASP1 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated LASP1 data layer compared with 27 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher LASP1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated LASP1 expression acts as an unfavorable survival marker.

HNSC, LSCC, and PDAC are the cancer types where LASP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.773	0.922	.001	38	view →
LSCC	DFS	Median	II,III,IV	0.492	0.842	.002	37	view →
PDAC	DFS	Median	IV	0.214	0.785	.006	9	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

LASP1–HNSC (OS)

Open the HNSC breakdown →