LASP1

Across TCGA patient cohorts, LASP1 mutation is significantly associated with the RNA expression of many other genes, with 1,830 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LASP1-associated genes across cancer lineages are RPL22P14, FAM243A, and GPAA1P1. Each is linked with LASP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LASP1-to-partner and partner-to-LASP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL22P14 grouped by LASP1-low versus LASP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LASP1→partner) and Y-score (partner→LASP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RPL22P14 →	+0.073	+2.109	.003	.005	3	2
UCEC	FAM243A →	+0.013	+4.744	<.001	.001	3	2
LUAD	GPAA1P1 →	+0.043	+5.584	<.001	.002	3	2
SKCM	RNU6-768P →	+0.543	+7.816	<.001	.008	3	2
COAD	LINC01795 →	+0.174	+5.283	<.001	.006	3	1
COAD	AP1B1P2 →	+0.674	+5.602	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,830 associations by consensus.

RPL22P14 by LASP1 expression — UCEC

Explore this box plot interactively →