LASP1

Across TCGA cell cohorts, LASP1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,267 significant associations in total. BONE shows the largest number of these associations.

The most reproducible LASP1-associated GO terms across cancer lineages are Positive regulation of cell-matrix adhesion, Rho protein signal transduction, and Positive regulation of cellular response to transforming growth factor beta stimulus. Each is linked with LASP1 in more than 14 cancer types. Because this analysis shows association rather than direction, both LASP1-to-partner and partner-to-LASP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of cell-matrix adhesion grouped by LASP1-low versus LASP1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LASP1→partner) and Y-score (partner→LASP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of cell-matrix adhesion →	+0.189	+1.644	<.001	<.001	3	15
BONE	Rho protein signal transduction →	+0.124	+1.254	<.001	.001	3	15
BONE	Positive regulation of cellular response to transforming growth factor beta stimulus →	+0.129	+1.308	<.001	<.001	3	14
BONE	Regulation of miRNA metabolic process →	+0.123	+1.680	<.001	<.001	3	14
BONE	Positive regulation of transforming growth factor beta receptor signaling pathway →	+0.129	+1.308	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Regulation of Golgi inheritance →	+0.182	+1.125	.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,267 associations by consensus.

Positive regulation of cell-matrix adhesion by LASP1 expression — BONE

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