LAS1L

Across TCGA pan-cancer cohorts, LAS1L Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated LAS1L data layer compared with 25 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher LAS1L Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated LAS1L expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUAD show a favorable association.

ESCA, MESO, and LGG are the cancer types where LAS1L Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Median	II,III,IV	0.198	0.702	.003	12	view →
MESO	DFS	Median	All	0.098	0.366	.039	6	view →
LGG	OS	Median	All	0.396	0.831	.017	6	view →
SCLC	OS	Median	II,III,IV	0.203	0.830	.011	6	view →
UCEC	DFS	Median	All	0.950	0.827	.022	6	view →
SKCM	OS	Median	III,IV	0.353	0.729	.032	3	view →
LUAD	DFS	Median	All	1.000	0.300	.042	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

LAS1L–ESCA (OS)

Open the ESCA breakdown →