LAS1L

Across TCGA pan-cancer cohorts, LAS1L mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated LAS1L data layer compared with 25 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher LAS1L mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated LAS1L expression acts as an unfavorable survival marker, although some lineages such as LUAD and HNSC show a favorable association.

LUAD, PDAC, and CCRCC are the cancer types where LAS1L mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	1.000	0.921	.001	48	view →
PDAC	DFS	Quartile	II,III,IV	0.529	0.835	.006	22	view →
CCRCC	DFS	Quartile	All	0.824	0.938	.036	6	view →
LSCC	DFS	Quartile	III,IV	0.627	0.970	.047	4	view →
HNSC	OS	Median	III,IV	0.791	0.569	.036	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

LAS1L–LUAD (OS)

Open the LUAD breakdown →