LARS2

Across TCGA patient cohorts, LARS2 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LARS2-associated genes across cancer lineages are ERK2, MEK1, and Caspase-7-cleavedD198. Each is linked with LARS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both LARS2-to-partner and partner-to-LARS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by LARS2-low versus LARS2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LARS2→partner) and Y-score (partner→LARS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.178	+1.807	.010	.025	3	2
UCEC	MEK1 →	+0.427	+2.807	.001	<.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.863	+2.827	<.001	.001	3	2
UCEC	eIF4E →	+0.209	+1.925	.005	.005	2	2
UCEC	FOXO3a_pS318_S321 →	-0.117	-2.405	.009	.003	3	1
UCEC	Ku80 →	+0.182	+1.939	.032	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

ERK2 by LARS2 expression — UCEC

Explore this box plot interactively →