LARS2

Across TCGA cell cohorts, LARS2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,399 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LARS2-associated GO terms across cancer lineages are Nucleosome disassembly, rRNA 5'-end processing, and Amino acid activation. Each is linked with LARS2 in more than 17 cancer types. Because this analysis shows association rather than direction, both LARS2-to-partner and partner-to-LARS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nucleosome disassembly grouped by LARS2-low versus LARS2-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LARS2→partner) and Y-score (partner→LARS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Nucleosome disassembly →	+0.158	+0.985	<.001	<.001	3	18
LIVER	rRNA 5'-end processing →	+0.132	+0.609	<.001	<.001	3	16
LIVER	Amino acid activation →	+0.130	+0.997	<.001	<.001	3	16
LIVER	tRNA aminoacylation →	+0.130	+0.997	<.001	<.001	3	16
LIVER	Endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.132	+0.609	<.001	<.001	3	16
BONE	Regulation of translational fidelity →	+0.133	+0.783	.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,399 associations by consensus.

Nucleosome disassembly by LARS2 expression — OVARY

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