LARS2

Across TCGA cell cohorts, LARS2 mutation is significantly associated with the RNA expression of many other genes, with 199 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LARS2-associated genes across cancer lineages are HIGD1C, DEFB105A, and IFNA7. Each is linked with LARS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both LARS2-to-partner and partner-to-LARS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HIGD1C grouped by LARS2-low versus LARS2-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LARS2→partner) and Y-score (partner→LARS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	HIGD1C →	+0.093	+3.672	.008	.006	3	1
LUNG_SCLC	DEFB105A →	+0.150	+4.643	<.001	.004	3	1
LUNG_SCLC	IFNA7 →	+0.255	+4.643	<.001	.004	3	1
SKIN	PDILT →	+0.051	+4.415	<.001	.007	3	1
BLOOD_Leukemia	IQCF5 →	+0.121	+5.201	<.001	.006	3	1
LARGE_INTESTINE	CBY1 →	+0.669	+3.330	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 199 associations by consensus.

HIGD1C by LARS2 expression — BREAST

Explore this box plot interactively →